Genetic Determinants of Periosteum Mediated Craniofacial Bone Regeneration: A Systematic Review

Background: Periosteum-mediated bone regeneration (PMBR) is a known mandibular reconstruction. Though poorly understood and unpredictable, the concerns of developmental changes to donor recipient tissues shared by other treatment options appear nonexistent. The definitive role periosteum during in any mammal remains understood.
 Objective: To characterise genetic determinants PMBR mammals through systematic review.
 Methods: Our search methodology was modeled after PRISMA (Preferred Reporting Items for Systematic Review Meta-Analysis) guidelines. quality assessment each publication undertaken differences gene expression at time points weeks 1 2 were appraised
 Results: A total 4 studies met inclusion criteria. study subjects studied 3 rat calvaria calf transplanted on mice. One out had score requisite ≥3. results showed an upregulation genes responsible angiogenesis, cytokine activities, immune-inflammatory response week-1, skeletal development signaling pathways, week-2
 Conclusion: suggest that morphogenesis regulated pathways may patterns PMBR